marginalianoun
notes written in the margins; peripheral commentary;


[marginalium]

A personalised alternative to antidepressants is on the way

15 Mar 2023

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A personalised alternative to antidepressants is on the way:

the treatment of depression is currently evolving in unexpected ways. This is based on a shift away from thinking about depression as a disorder of ‘chemicals in the brain’ to an understanding that depression is underpinned by changes in electrical activity and communication between brain regions.

but

At times, this resistance seems to reflect a perhaps wilful ignorance of evidence or even an ideological approach to medicine rather than an evidence-based one. There is a danger that a highly novel treatment, such as home-based closed-loop stimulation, will produce a similar degree of professional resistance, especially given that treatment informed by artificial intelligence could be seen to reduce the role of the clinician in the decision-making process.


Anthologies: Gratification, Somatic Architecture, Neurotypica, On (Un)happiness, On Thinking and Reasoning

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More about Dorian Minors' project btrmt.

btrmt. (text-only version)

The full site with interactive features is available at btr.mt.

btrmt. (betterment) examines ideologies worth choosing. Created by Dorian Minors—Cambridge PhD in cognitive neuroscience, Associate Professor at Royal Military Academy Sandhurst. Core philosophy: humans are animals first, with automatic patterns shaped for us, not by us. Better to examine and choose.

Core concepts. Animals First: automatic patterns of thought and action, but our greatest capacity is nurture. Half Awake: deadened by systems that narrow rather than expand potential. Karstica: unexamined ideologies (hidden sinkholes beneath). Credenda: belief systems we should choose deliberately.

The manifesto. Cynosure (focus): betterment, gratification, connection. Architecture (support): inner (somatic, spiritual, thought) and outer (digital, collective, wealth).

Mission. Not answers but examination. Break academic gatekeeping. Make sciences of mind accessible. Question rather than prescribe.

Writing style. Scholarly without jargon barriers. Philosophical yet practical—grounded in neuroscience and lived experience. Reflective, discovery-oriented. Literary references and metaphor. Critical of systems that narrow human potential. Rejects "humans are flawed"—we're half awake, not broken.

Copyright. BTRMT LIMITED (England/Wales no. 13755561) 2026. Dorian Minors 2026.

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About Dorian Minors. Started btrmt. in 2013 to share sciences of mind with people who weren't studying them. Background: six years Australian Defence Force (Platoon Commander, Infantry); Gates Cambridge Scholar; PhD cognitive neuroscience, University of Cambridge (2018-2024); currently Associate Professor, Royal Military Academy Sandhurst. Research interests: neural basis of intelligent behaviour, decision intelligence, ritual formation/breakdown, ethical leadership, wellbeing.

External projects (links also available via Analects):