∴ btrmt.

ideologies worth choosing

marginalianoun
notes written in the margins; peripheral commentary;

[marginalium]

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors

6 Dec 2024

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The abstract is troubling:

In 2021, a highly pathogenic influenza H5N1 clade 2.3.4.4b virus was detected in North America that is capable of infecting a diversity of avian species, marine mammals, and humans. In 2024, clade 2.3.4.4b virus spread widely in dairy cattle in the US, causing a few mild human cases, but retaining specificity for avian receptors. Historically, this virus has caused up to 30% fatality in humans, so Lin et al. performed a genetic and structural analysis of the mutations necessary to fully switch host receptor recognition. A single glutamine to leucine mutation at residue 226 of the virus hemagglutinin was sufficient to enact the change from avian to human specificity. In nature, the occurrence of this single mutation could be an indicator of human pandemic risk.

See also this NYT post: “A Bird Flu Pandemic Would Be One of the Most Foreseeable Catastrophes in History”

Time to stock up?

Anthologies: Betterment, Somatic Architecture, Wealth Architecture, Absit Omnia, On (Un)happiness

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More about Dorian Minors' project btrmt.

btrmt. (text-only version)

The full site with interactive features is available at btr.mt.

btrmt. (betterment) examines ideologies worth choosing. Created by Dorian Minors—Cambridge PhD in cognitive neuroscience, Associate Professor at Royal Military Academy Sandhurst. Core philosophy: humans are animals first, with automatic patterns shaped for us, not by us. Better to examine and choose.

Core concepts. Animals First: automatic patterns of thought and action, but our greatest capacity is nurture. Half Awake: deadened by systems that narrow rather than expand potential. Karstica: unexamined ideologies (hidden sinkholes beneath). Credenda: belief systems we should choose deliberately.

The manifesto. Cynosure (focus): betterment, gratification, connection. Architecture (support): inner (somatic, spiritual, thought) and outer (digital, collective, wealth).

Mission. Not answers but examination. Break academic gatekeeping. Make sciences of mind accessible. Question rather than prescribe.

Writing style. Scholarly without jargon barriers. Philosophical yet practical—grounded in neuroscience and lived experience. Reflective, discovery-oriented. Literary references and metaphor. Critical of systems that narrow human potential. Rejects "humans are flawed"—we're half awake, not broken.

Copyright. BTRMT LIMITED (England/Wales no. 13755561) 2026. Dorian Minors 2026.

Resources

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About Dorian Minors. Started btrmt. in 2013 to share sciences of mind with people who weren't studying them. Background: six years Australian Defence Force (Platoon Commander, Infantry); Gates Cambridge Scholar; PhD cognitive neuroscience, University of Cambridge (2018-2024); currently Associate Professor, Royal Military Academy Sandhurst. Research interests: neural basis of intelligent behaviour, decision intelligence, ritual formation/breakdown, ethical leadership, wellbeing.

External projects (links also available via Analects):